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Mult Scler. 2017 Feb;23(2):228-233. doi: 10.1177/1352458516663853. Epub 2016 Sep 28.

The impact of 2015 neuromyelitis optica spectrum disorders criteria on diagnostic rates.

Author information

1
The Walton Centre, NHS Foundation Trust, Liverpool, UK.
2
Institute of Infectious Disease and Global Health, University of Liverpool, Liverpool, UK/The Walton Centre, NHS Foundation Trust, Liverpool, UK.

Abstract

BACKGROUND:

The international panel for neuromyelitis optica (NMO) diagnosis has proposed diagnostic criteria for neuromyelitis optica spectrum disorders (NMOSD).

OBJECTIVES:

We assessed the impact of these criteria on diagnostic rates in a large cohort of patients.

METHODS:

We identified and applied the 2006 and 2015 criteria to all patients ( nā€‰=ā€‰176) seen in the NMO and non-multiple sclerosis central nervous system demyelination clinic (part of the UK NMO service) from January 2013 to May 2015.

RESULTS:

The 2006 criteria classified 63 of 176 (36%) patients as NMO. A total of 42 patients (67%) were aquaporin 4 (AQP4) immunoglobulin G (IgG) +ve and 21 (33%) AQP4 IgG -ve. The 2015 criteria classified 111 of 176 (63%) patients as NMOSD, of which 81 (73%) were AQP4 IgG +ve and 30 (27%) were AQP4 IgG -ve. There was an increase of 48 patients (76%) diagnosed as NMOSD using the new criteria.

CONCLUSION:

Application of the 2015 criteria led to a rise in diagnosis of NMOSD by 76%. The rise in the AQP4 IgG +ve group contributed 62% and the seronegative group contributed 14%.

KEYWORDS:

Neuromyelitis optica spectrum disorders; central nervous system demyelination; criteria; multiple sclerosis

PMID:
27553618
DOI:
10.1177/1352458516663853
[Indexed for MEDLINE]

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