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Stroke. 2016 Oct;47(10):2618-26. doi: 10.1161/STROKEAHA.116.013059. Epub 2016 Aug 23.

Sex Disparities in Ischemic Stroke Care: FL-PR CReSD Study (Florida-Puerto Rico Collaboration to Reduce Stroke Disparities).

Author information

1
From the Department of Neurology, University of Miami Miller School of Medicine, FL (N.A., J.G.R., K.W., M.A.C-.V., S.K., H.G., C.D., R.L.S., T.R.); Department of Neurology, University of South Florida School of Medicine, Tampa (D.Z.R., W.S.B.); National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.); The American Heart Association, Greater Southeast Affiliate, Marietta, GA (M.R.); and Endowed Health Services Research Center (E.J.G.) and Department of Emergency Medicine (J.A.G-.S.), University of Puerto Rico School of Medicine, San Juan. nasdaghi@med.miami.edu.
2
From the Department of Neurology, University of Miami Miller School of Medicine, FL (N.A., J.G.R., K.W., M.A.C-.V., S.K., H.G., C.D., R.L.S., T.R.); Department of Neurology, University of South Florida School of Medicine, Tampa (D.Z.R., W.S.B.); National Institute of Neurological Disorders and Stroke, Bethesda, MD (S.P.W.); The American Heart Association, Greater Southeast Affiliate, Marietta, GA (M.R.); and Endowed Health Services Research Center (E.J.G.) and Department of Emergency Medicine (J.A.G-.S.), University of Puerto Rico School of Medicine, San Juan.

Abstract

BACKGROUND AND PURPOSE:

Sex-specific disparities in stroke care including thrombolytic therapy and early hospital admission are reported. In a large registry of Florida and Puerto Rico hospitals participating in the Get With The Guidelines-Stroke program, we sought to determine sex-specific differences in ischemic stroke performance metrics and overall thrombolytic treatment.

METHODS:

Around 51 317 (49% women) patients were included from 73 sites from 2010 to 2014. Multivariable logistic regression with generalized estimating equations evaluated sex-specific differences in the prespecified Get With The Guidelines-Stroke metrics for defect-free care in ischemic stroke, adjusting for age, race-ethnicity, insurance status, hospital characteristics, individual risk factors, and the presenting stroke severity.

RESULTS:

As compared with men, women were older (73±15 versus 69±14 years; P<0.0001), more hypertensive (67% versus 63%, P<0.0001), and had more atrial fibrillation (19% versus 16%; P<0.0001). Defect-free care was slightly lower in women than in men (odds ratio, 0.96; 95% confidence interval, 0.93-1.00). Temporal trends in defect-free care improved substantially and similarly for men and women, with a 29% absolute improvement in women (P<0.0001) and 28% in men (P<0.0001), with P value of 0.13 for time-by-sex interaction. Women were less likely to receive thrombolysis (odds ratio, 0.92; 95% confidence interval, 0.86-0.99; P=0.02) and less likely to have a door-to-needle time <1 hour (odds ratio, 0.83; 95% confidence interval, 0.71-0.97; P=0.02) as compared with men.

CONCLUSIONS:

Women received comparable stroke care to men in this registry as measured by prespecified Get With The Guidelines metrics. However, women less likely received thrombolysis and had door-to-needle time <1 hour, an observation that calls for the implementation of interventions to reduce sex disparity in these measures.

KEYWORDS:

Get With The Guidelines; National Institute of Neurological Disorders and Stroke; sex characteristics; stroke

PMID:
27553032
PMCID:
PMC5039084
DOI:
10.1161/STROKEAHA.116.013059
[Indexed for MEDLINE]
Free PMC Article

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