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Fitoterapia. 2016 Oct;114:18-25. doi: 10.1016/j.fitote.2016.08.008. Epub 2016 Aug 20.

Mechanism of action of herbs and their active constituents used in hair loss treatment.

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Faculty of Cosmetology, The Academy of Cosmetics and Health Care, Podwale 13 street, 00-252 Warsaw, Poland. Electronic address:
Laboratory of Molecular Biology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3 street, 05-110 Jabłonna, near Warsaw, Poland.


This article discusses the mechanisms via topically applied products containing herbs and their active constituents affect the hair growth process. It was reported that the mechanisms involving (1) insulin-like growth factor-I (IGF-I), (2) vascular endothelial growth factor (VEGF), (3) epidermal growth factor (EGF), (4) fibroblast growth factor 2 (FGF-2), (5) endothelial nitric oxide synthase (eNOS), (6) Wnt/β-catenin signalling pathway, (7) prostaglandin E (PGE), (8) prostaglandin F (PGF) stimulate hair growth, whereas the mechanisms engaging (1) 5α-reductase and dihydrotestosterone (DHT), (2) transforming growth factor beta (TGF-β), (3) fibroblast growth factor 5 (FGF-5), (4) prostaglandin D2 (PGD2) inhibit hair growth. The knowledge summarized in the paper may be an inspiration to create new preparations for the treatment of hair loss.


Hair growth; Hair loss; Herbs; Herbs active constituents; Mechanism of action

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