Format

Send to

Choose Destination
Antimicrob Agents Chemother. 2016 Oct 21;60(11):6899-6902. doi: 10.1128/AAC.01365-16. Print 2016 Nov.

Emergence of NDM-5- and MCR-1-Producing Escherichia coli Clones ST648 and ST156 from a Single Muscovy Duck (Cairina moschata).

Yang RS1,2, Feng Y3, Lv XY1,2, Duan JH1,2, Chen J1,2, Fang LX1,2, Xia J1,2, Liao XP1,2, Sun J4,2, Liu YH4,2.

Author information

1
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China.
2
Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, People's Republic of China.
3
Department of Medical Microbiology and Parasitology, Zhejiang University School of Medicine, Zhejiang, People's Republic of China.
4
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, People's Republic of China jiansun@scau.edu.cn lyh@scau.edu.cn.

Abstract

Two Escherichia coli clones (sequence type 648 [ST648] and ST156) that coproduce NDM-5 and MCR-1 were detected from a single fowl in China. The blaNDM-5 gene was found on the two indistinguishable IncX3 plasmids from the two different E. coli isolates, whereas the mcr-1 gene was located on IncHI2 and IncI2 plasmids, respectively, suggesting that blaNDM-5 and mcr-1 have spread in avian intestinal flora. Also, the two strains harbor blaTEM-1, blaCTX-M-55, fosA3, and aac(6')-Ib The multiresistant E. coli strains (especially the epidemic clone ST648) might raise a potential threat to human health via food chain transmission.

PMID:
27550364
PMCID:
PMC5075103
DOI:
10.1128/AAC.01365-16
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center