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F1000Res. 2016 Aug 3;5. pii: F1000 Faculty Rev-1909. doi: 10.12688/f1000research.8881.1. eCollection 2016.

Recent advances in cohesin biology.

Author information

1
Program in Cell Cycle and Cancer Biology, Oklahoma Medicial Research Foundation, Oklahoma City, Oklahoma, USA.
2
Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
#
Contributed equally

Abstract

Sister chromatids are tethered together from the time they are formed in S-phase until they separate at anaphase. A protein complex called cohesin is responsible for holding the sister chromatids together and serves important roles in chromosome condensation, gene regulation, and the repair of DNA damage. Cohesin contains an open central pore and becomes topologically engaged with its DNA substrates. Entrapped DNA can be released either by the opening of a gate in the cohesin ring or by proteolytic cleavage of a component of the ring. This review summarizes recent research that provides important new insights into how DNA enters and exits the cohesin ring and how the rings behave on entrapped DNA molecules to provide functional cohesion.

KEYWORDS:

chromosome; cohesin; mitosis

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