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World J Gastroenterol. 2016 Aug 7;22(29):6610-8. doi: 10.3748/wjg.v22.i29.6610.

Noncoding RNAs in gastric cancer: Research progress and prospects.

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Meng Zhang, Xiang Du, Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.


Noncoding RNAs (ncRNAs) have attracted much attention in cancer research field. They are involved in cellular development, proliferation, differentiation and apoptosis. The dysregulation of ncRNAs has been reported in tumor initiation, progression, invasion and metastasis in various cancers, including gastric cancer (GC). In the past few years, an accumulating body of evidence has deepened our understanding of ncRNAs, and several emerging ncRNAs have been identified, such as PIWI-interacting RNAs (piRNAs) and circular RNAs (circRNAs). The competing endogenous RNA (ceRNA) networks include mRNAs, microRNAs, long ncRNAs (lncRNAs) and circRNAs, which play critical roles in the tumorigenesis of GC. This review summarizes the recent hotspots of ncRNAs involved in GC pathobiology and their potential applications in GC. Finally, we briefly discuss the advances in the ceRNA network in GC.


Competing endogenous RNA; Gastric cancer; Long ncRNAs; MicroRNA; Noncoding RNAs; PIWI-interacting RNAs

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