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Sci Rep. 2016 Aug 22;6:31609. doi: 10.1038/srep31609.

Body Mass Index and Mortality: A 10-Year Prospective Study in China.

Author information

1
Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University, Hangzhou 310058, China.
2
Research Center for Air Pollution and Health, Zhejiang University, Hangzhou 310058, China.
3
Yinzhou District Center for Disease Control and Prevention, Ningbo, 315100, China.
4
Zhejiang Cancer Hospital, 310022, China.
5
Michigan State University, 48824, USA.

Abstract

Although several studies have evaluated the role of body weight as a risk factor for mortality, most studies have been conducted in Western populations and the findings remain controversial. We performed a prospective study to examine the association between body mass index (BMI) and all-cause mortality in Yinzhou District, Ningbo, China. At baseline, 384,533 subjects were recruited through the Yinzhou Health Information System between 2004 and 2009. The final analysis was restricted to 372,793 participants (178,333 men and 194,460 women) aged 18 years and older. Cox proportional hazards models were used to estimate hazard ratios(HRs) and 95% confidence intervals(CIs). We found an increased risk of all-cause mortality among individuals with BMI levels <22.5-24.9, although several groups were not statistically significant-adjusted HRs for persons with BMIs of <15.0, 15.0-17.4, 17.5-19.9, and 20.0-22.4 were 1.61(95% CI: 1.17-2.23), 1.07(0.94-1.20), 1.04(0.98-1.10), 1.06(1.02-1.11), respectively. In the upper BMI range, subjects with BMIs of 25.0-34.9 had a reduced risk of all-cause mortality. Sensitivity analyses excluding smokers, those with prevalent chronic disease or those with less than four years of follow-up did not materially alter these results. Our findings provide evidence for an inverse association of BMI and mortality in this population.

PMID:
27546611
PMCID:
PMC4992855
DOI:
10.1038/srep31609
[Indexed for MEDLINE]
Free PMC Article

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