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Can J Diabetes. 2016 Dec;40(6):586-593. doi: 10.1016/j.jcjd.2016.05.002. Epub 2016 Aug 18.

Environmental Risk Factors and Type 1 Diabetes: Past, Present, and Future.

Author information

1
Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address: sbutalia@ucalgary.ca.
2
Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.
3
Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.
4
Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Cardiac Sciences, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

Abstract

Type 1 diabetes is an autoimmune condition that results from the destruction of the insulin-producing beta cells of the pancreas. The excess morbidity and mortality resulting from its complications, coupled with its increasing incidence, emphasize the importance of better understanding the causes of this condition. Over the past several decades, a substantive amount of work has been done and, although many advances have occurred in identifying disease-susceptibility genes, there has been a lag in understanding the environmental triggers. Several putative environmental risk factors have been proposed, including infections, dietary factors, air pollution, vaccines, location of residence, family environment and stress. However, most of these factors have been inconclusive, thus supporting the need for further study into the causes of type 1 diabetes.

KEYWORDS:

diab├Ęte de type 1; environment; environnement; examen; expositions; exposures; facteurs de risque; review; risk factors; type 1 diabetes

PMID:
27545597
DOI:
10.1016/j.jcjd.2016.05.002
[Indexed for MEDLINE]

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