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J Dermatol Sci. 2016 Nov;84(2):178-185. doi: 10.1016/j.jdermsci.2016.08.007. Epub 2016 Aug 9.

Dose dependent sun protective effect of topical melatonin: A randomized, placebo-controlled, double-blind study.

Author information

1
Køge Hospital - University of Copenhagen, Department of Surgery, Lykkebækvej 1, DK-4600 Køge, Denmark. Electronic address: cili_scheuer@hotmail.com.
2
Herlev Hospital - University of Copenhagen, Department of Surgery, Herlev Ringvej 75, DK- 2730 Herlev, Denmark; Hvidovre Hospital - University of Copenhagen, Department of Surgery, Kettegård Alle 30, DK - 2650 Hvidovre, Denmark.
3
Herlev Hospital - University of Copenhagen, Department of Surgery, Herlev Ringvej 75, DK- 2730 Herlev, Denmark.
4
Køge Hospital - University of Copenhagen, Department of Surgery, Lykkebækvej 1, DK-4600 Køge, Denmark.

Abstract

BACKGROUND:

Ultraviolet radiation (UVR) by sunlight results in an increasing number of skin conditions. Earlier studies have suggested a protective effect of topical treatment with the pineal hormone melatonin. However, this protective effect has never been evaluated in natural sunlight, and the optimal dosing has not been clarified.

OBJECTIVE:

The aim of this study was to investigate the sun protective effect of topical treatment with three different doses of melatonin (0.5%, 2.5%, 12.5%) against erythema induced by natural sunlight.

METHOD:

The study was a randomized, placebo-controlled, double-blind study in healthy volunteers. Twenty-three healthy volunteers, 8 male and 15 female, were enrolled. The protective effect of three different doses of melatonin cream (0.5%, 2.5%, 12.5%) against erythema induced by natural sunlight was tested. All participants had their backs exposed to sun from 1:22 PM to 2:02 PM local time and UV-index was 9. Primary outcome was reduction in erythema evaluated by chromatography after sun exposure, when treated with topical melatonin cream (0.5%, 2.5%, 12.5%) versus placebo and no treatment. The erythema reaction was evaluated with chromatography and visual scoring at baseline, one, four, eight and 24h after exposure.

RESULTS:

Significant difference in erythema formation was found between areas treated with melatonin cream 12.5% and areas receiving placebo or no treatment (repeated measures ANOVA p=0.001). No differences were found between placebo and the 0.5% and 2.5% concentrations.

CONCLUSION:

Application of melatonin cream 12.5% protects against natural sunlight induced erythema.

KEYWORDS:

Natural sun exposure; Non-melanoma skincancer; Topical melatonin

PMID:
27543364
DOI:
10.1016/j.jdermsci.2016.08.007
[Indexed for MEDLINE]

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