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Curr Diab Rep. 2016 Oct;16(10):93. doi: 10.1007/s11892-016-0791-x.

Diet and Gut Microbial Function in Metabolic and Cardiovascular Disease Risk.

Author information

1
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2003 Michael Hooker Research Center, CB no. 7461, Chapel Hill, NC, 27599, USA. ktmeyer@unc.edu.
2
Nutrition Research Institute, University of North Carolina at Chapel Hill, 500 Laureate Way, Kannapolis, NC, 28081, USA. ktmeyer@unc.edu.
3
Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2003 Michael Hooker Research Center, CB no. 7461, Chapel Hill, NC, 27599, USA.
4
Nutrition Research Institute, University of North Carolina at Chapel Hill, 500 Laureate Way, Kannapolis, NC, 28081, USA.
5
Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Abstract

Over the past decade, the gut microbiome has emerged as a novel and largely unexplored source of variability for metabolic and cardiovascular disease risk, including diabetes. Animal and human studies support several possible pathways through which the gut microbiome may impact health, including the production of health-related metabolites from dietary sources. Diet is considered important to shaping the gut microbiota; in addition, gut microbiota influence the metabolism of many dietary components. In the present paper, we address the distinction between compositional and functional analysis of the gut microbiota. We focus on literature that highlights the value of moving beyond surveys of microbial composition to measuring gut microbial functioning to delineate mechanisms related to the interplay between diet and gut microbiota in cardiometabolic health.

KEYWORDS:

Cardiovascular disease; Diabetes; Gut microbiota; Metabolites; Nutrition

PMID:
27541295
PMCID:
PMC5248533
DOI:
10.1007/s11892-016-0791-x
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

Compliance with Ethics Guidelines Conflicts of Interest Katie A. Meyer has received research grants from the Egg Nutrition Center and from the National Institute of Health (K01-HL127159). Brian J. Bennett has received research grants from the National Institutes of Health.

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