IRE1 Sulfenylation by Reactive Oxygen Species Coordinates Cellular Stress Signaling

Mol Cell. 2016 Aug 18;63(4):541-542. doi: 10.1016/j.molcel.2016.08.003.

Abstract

In this issue of Molecular Cell, Hourihan et al. (2016) show that sulfenylation of IRE1 by reactive oxygen species inhibits the role of IRE1 in the Unfolded Protein Response and activates a SKN-1/Nrf2-dependent response to oxidative stress.

Publication types

  • Comment

MeSH terms

  • Oxidative Stress
  • Protein Serine-Threonine Kinases / genetics
  • Reactive Oxygen Species*
  • Signal Transduction
  • Unfolded Protein Response*

Substances

  • Reactive Oxygen Species
  • Protein Serine-Threonine Kinases