Format

Send to

Choose Destination
Zh Vyssh Nerv Deiat Im I P Pavlova. 2016 Mar-Apr;66(2):131-47.

[GABA-Receptors in Modulation of Fear Memory Extinction].

[Article in Russian]

Abstract

GABA is the major inhibitory neurotransmitter in the central nervous system determining the efficacy of neuronal interaction. GABA-receptors play a key role in different aspects of fear memory--acquisition and consolidation, retention, reconsolidation and extinction. Extinction is an important behavioural phenomenon which allows organism to adapt its behavior to a changing environment. Extinction of fear memory is a form of new inhibitory learning which interferes with expression of the initial acquired fear conditioning. Resistance to extinction is symptom of depression and posttraumatic stress disorder. The aim of the present review was to summarize own and literary data about GABAergic modulation of fear extinction and pharmacological correction of extinction impairment at influences on GABA(A)- and GABA(B)- receptors.

PMID:
27538279
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center