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Br J Cancer. 2016 Sep 27;115(7):761-9. doi: 10.1038/bjc.2016.255. Epub 2016 Aug 18.

Transforming growth factor β as regulator of cancer stemness and metastasis.

Author information

1
Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Box 582, SE 751 23 Uppsala, Sweden.
2
Ludwig Institute for Cancer Research, Science for Life Laboratory, Uppsala University, Box 595, SE 751 24 Uppsala, Sweden.

Abstract

Key elements of cancer progression towards metastasis are the biological actions of cancer stem cells and stromal cells in the tumour microenvironment. Cross-communication between tumour and stromal cells is mediated by secreted cytokines, one of which, the transforming growth factor β (TGFβ), regulates essentially every cell within the malignant tissue. In this article, we focus on the actions of TGFβ on cancer stem cells, cancer-associated fibroblasts and immune cells that assist the overall process of metastatic dissemination. We aim at illustrating intricate connections made by various cells in the tumour tissue and which depend on the action of TGFβ.

PMID:
27537386
PMCID:
PMC5046208
DOI:
10.1038/bjc.2016.255
[Indexed for MEDLINE]
Free PMC Article

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