Format

Send to

Choose Destination
Br J Cancer. 2016 Sep 27;115(7):862-5. doi: 10.1038/bjc.2016.245. Epub 2016 Aug 18.

Mediterranean diet and colorectal cancer risk: a pooled analysis of three Italian case-control studies.

Author information

1
Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
2
Unit of Medical Statistics, Biometry and Bioinformatics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
3
Department of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche 'Mario Negri', Milan, Italy.
4
Unit of Epidemiology and Biostatistics, Centro di Riferimento Oncologico Aviano IRCCS, Aviano, Italy.
5
Department of Gastroenterology and Clinical Nutrition, Policlinico di Monza, Monza, Italy.
6
Epidemiology Unit, National Cancer Institute, 'G. Pascale' Foundation, Naples, Italy.

Abstract

BACKGROUND:

Adherence to the Mediterranean diet (MD) is associated with a reduced risk of several cancers. However, studies conducted in Mediterranean regions are scanty.

METHODS:

To investigate the relation between MD and colorectal cancer risk in Italy, we pooled data from three case-control studies, including a total of 3745 colorectal cancer cases and 6804 hospital controls. Adherence to the MD was assessed using an a priori Mediterranean Diet Score (MDS), based on nine components.

RESULTS:

Compared with the lowest adherence to the MD (0-2 MDS), the odds ratio (OR) was 0.52 (95% confidence interval (CI) 0.43-0.62) for the highest adherence (7-9 MDS), with a significant inverse trend in risk (P<0.0001). The OR for a 1-point increment in the MDS was 0.89 (95% CI 0.86-0.91). The inverse association was consistent across studies, cancer anatomical subsites and strata of selected covariates.

CONCLUSIONS:

This Italian study confirms a favourable role of MD on colorectal cancer risk.

PMID:
27537381
PMCID:
PMC5046203
DOI:
10.1038/bjc.2016.245
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center