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BMC Pregnancy Childbirth. 2016 Aug 17;16:231. doi: 10.1186/s12884-016-1030-9.

Use of the National Diabetes Data Group and the Carpenter-Coustan criteria for assessing gestational diabetes mellitus and risk of adverse pregnancy outcome.

Lu MC1, Huang SS2, Yan YH1,3,4,5, Wang P6.

Author information

1
Department of Medical Research, Kuang Tien General Hospital, Taichung, Taiwan.
2
Department of Obstetrics and Gynecology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, 539 Chung-Shau Road, Chia-Yi City, 600, Taiwan.
3
Department of Internal Medicine, Kuang Tien General Hospital, Taichung, Taiwan.
4
Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan.
5
Department of Nutrition and Institute of Biomedical Nutrition, Hung Kuang University, Taichung, Taiwan.
6
Department of Obstetrics and Gynecology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, 539 Chung-Shau Road, Chia-Yi City, 600, Taiwan. cych10613@gmail.com.

Abstract

BACKGROUND:

The influence of different diagnostic thresholds for gestational diabetes mellitus (GDM) on pregnancy outcomes is not fully understood. Degrees of glucose intolerance according to the Carpenter-Coustan (CC) criteria were less severe than the National Diabetes Data Group (NDDG) criteria for GDM. Recent studies have shown inconsistent results regarding the risk of adverse pregnancy outcomes between the NDDG and CC criteria. Therefore, the objective of this study was to investigate whether pregnant women who met only the CC criteria but not the NDDG criteria and those who met the NDDG criteria had increased risks of adverse pregnancy outcomes compared to a negative screening group.

METHODS:

A total of 11,486 Taiwanese pregnancies were enrolled in a retrospective cohort study. The study subjects were classified as follows: (1) negative screening group: women with negative 50-g glucose challenge test (GCT) results, (2) false-positive screening group: women with positive GCT results and negative 100-g OGTT results according to both CC and NDDG criteria, (3) CC-only-GDM group: women with positive GCT results plus GDM diagnosis meeting the CC but not the NDDG criteria, and (4) NDDG-GDM group: women diagnosed with GDM using the NDDG criteria. Multiple mixed effects logistic regression analysis was used to examine the relationships between the groups and pregnancy outcomes.

RESULTS:

There were 9002 (78.4 %), 1776 (15.5 %), 251 (2.2 %), and 457 (4.0 %) study pregnancies in the 4 groups. Compared with the negative screening group, the maternal outcomes were not different within groups except for gestational hypertension/preeclampsia. For neonatal outcomes, the CC-only-GDM group had significantly greater risks of macrosomia, low birth weight, and admission to a neonatal intensive care unit [adjusted odds ratio (aOR), (95 % confidence interval, CI): 2.73 (1.18-6.31), 1.64 (1.01-2.64), and 1.61 (1.05-2.46), respectively]. The NDDG-GDM group also showed significantly greater risks, and the false-positive screening group showed no differences from the negative screening group.

CONCLUSION:

Women who met only the CC criteria and women who met NDDG criteria had significant increased risks of adverse neonatal outcomes. This evidence adds important information to the current debate about the diagnostic criteria for GDM regarding pregnancy outcomes.

KEYWORDS:

Admission to a neonatal intensive care unit; Adverse pregnancy outcome; Carpenter-Coustan criteria; Gestational diabetes mellitus; Macrosomia; National Diabetes Data Group criteria

PMID:
27535366
PMCID:
PMC4989365
DOI:
10.1186/s12884-016-1030-9
[Indexed for MEDLINE]
Free PMC Article

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