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Cancer Invest. 2016 Sep 13;34(8):373-7. doi: 10.1080/07357907.2016.1212061. Epub 2016 Aug 17.

Preoperative Percutaneous Transthoracic Needle Biopsy Increased the Risk of Pleural Recurrence in Pathological Stage I Lung Cancer Patients With Sub-pleural Pure Solid Nodules.

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a Department of Respiratory Medicine , Kumamoto Regional Medical Center , Kumamoto , Japan.


We retrospectively evaluated whether preoperative percutaneous transthoracic needle biopsy (PTNB) affected the incidence of pleural recurrence in pathological stage I lung cancer patients. Pleural recurrence occurred in pure solid nodule (PSN) cases but not in ground-glass nodule cases, as evaluated using thin-section computed tomographic imaging. When the cases were restricted to sub-pleural PSN, the incidence of recurrence tended to be higher in a PTNB group (63 patients diagnosed by PTNB) than in a non-PTNB group (86 patients diagnosed by transbronchial biopsy or intraoperative diagnosis) (25% vs. 4%, p =.050). PTNB should not be performed in patients with a sub-pleural PSN.


Pleural recurrence; needle-tract implantation; percutaneous transthoracic needle biopsy; pure solid nodule; sub-pleural location

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