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EBioMedicine. 2016 Sep;11:31-42. doi: 10.1016/j.ebiom.2016.07.039. Epub 2016 Aug 6.

Hepatitis E Virus Mutations: Functional and Clinical Relevance.

Author information

1
Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany. Electronic address: tong.van-hoang@uni-tuebingen.de.
2
Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
3
Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany.
4
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
5
Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany. Electronic address: bockc@rki.de.

Abstract

Hepatitis E virus (HEV) infection is a major cause of acute hepatitis and affects more than 20 million individuals, with three million symptomatic cases and 56,000 recognized HEV-related deaths worldwide. HEV is endemic in developing countries and is gaining importance in developed countries, due to increased number of autochthone cases. Although HEV replication is controlled by the host immune system, viral factors (especially specific viral genotypes and mutants) can modulate HEV replication, infection and pathogenesis. Limited knowledge exists on the contribution of HEV genome variants towards pathogenesis, susceptibility and to therapeutic response. Nonsynonymous substitutions can modulate viral proteins structurally and thus dysregulate virus-host interactions. This review aims to compile knowledge and discuss recent advances on the casual role of HEV heterogeneity and its variants on viral morphogenesis, pathogenesis, clinical outcome and antiviral resistance.

KEYWORDS:

HEV infection; HEV mutation; HEV replication; HEV treatment failure; HEV variability; Hepatitis E virus

PMID:
27528267
PMCID:
PMC5049923
DOI:
10.1016/j.ebiom.2016.07.039
[Indexed for MEDLINE]
Free PMC Article

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