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Curr Med Chem. 2018;25(39):5395-5431. doi: 10.2174/0929867323666160813222436.

Updates on Managing Type 2 Diabetes Mellitus with Natural Products: Towards Antidiabetic Drug Development.

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Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770, Australia.
Novel Global Community Educational Foundation 7 Peterlee Place, Hebersham, NSW 2770, Australia.


Over the years, natural products have shown success as antidiabetics in in vitro, in vivo studies and clinical trials. Because natural product-derived drugs are more affordable and effective with fewer side-effects compared to conventional therapies, pharmaceutical research is increasingly leaning towards the discovery of new antidiabetic drugs from natural products targeting pathways or components associated with type 2 diabetes mellitus (T2DM) pathophysiology. However, the drug discovery process is very lengthy and costly with significant challenges. Therefore, various techniques are currently being developed for the preclinical research phase of drug discovery with the aim of drug development with less time and efforts from natural products. In this review, we have provided an update on natural products including fruits, vegetables, spices, nuts, beverages and mushrooms with potential antidiabetic activities from in vivo, in vitro and clinical studies. Synergistic interactions between natural products and antidiabetic drugs, and potential antidiabetic active compounds from natural products are also documented to pave the way for combination treatment and new drug discovery, respectively. Additionally, a brief idea of the drug discovery process along with the challenges that arise during drug development from natural products and the methods to conquer those challenges are discussed to create a more convenient future drug discovery process.


Type 2 diabetes mellitus; antidiabetic drugs; drug development; in vitro; in vivo; natural products; synergistic interaction.

[Indexed for MEDLINE]

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