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Acta Medica (Hradec Kralove). 2016;59(2):67-9. doi: 10.14712/18059694.2016.92.

A rare case of Ganglioneuroblastoma Encapsulated in Pheochromocytoma.

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Faculdade de Medicina de Itajubá, Av. Renó Júnior, 368 - São Vicente, Itajubá, MG, Brazil.
Faculdade de Medicina de Itajubá, Av. Renó Júnior, 368 - São Vicente, Itajubá, MG, Brazil.
Programa de Pós-Graduação em Fisioterapia, Faculdade de Ciências e Tecnologia, UNESP, Rua Roberto Simonsen, 305, Presidente Prudente, SP, Brazil.
Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Gipsy Lane, Oxford OX3 0BP, United Kingdom.
Instituto Dante Pazzanese de Cardiologia, Av. Dr. Dante Pazzanese, 500, São Paulo, SP, Brazil.


Pheochromocytoma and Ganglioneuroblastoma are separate diseases and a rare combination in which the diagnosis can only be confirmed by pathological examination after tumor excision. We reported here a case of ganglioneuroblastoma encapsulated in pheochromocytoma. The patient is a woman, 73 years old, hypertensive, with hypothyroidism, associated for 15 years with hypercholesterolemia and hypertriglyceridemia, which had frequent complaints of low back pain. She underwent magnetic resonance and the findings were consistent with the diagnosis of pheochromocytoma. After surgery, anatomic, pathologic and immunohistochemistry analysis confirmed the diagnosis of pheochromocytoma composed by small ganglioneuroblastoma representation with the identification of small focus of infiltration of the adrenal capsule and adipose tissue by pheochromocytoma. This rare association can instigate the discussion of methods of diagnosis, more effective and more appropriate treatments for each patient.


Abdominal Neoplasms; Ganglioneuroblastoma; Pheochromocytoma

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