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Brain Inform. 2016 Mar 30;3(3):169-179. eCollection 2016 Sep.

Clusters of male and female Alzheimer's disease patients in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database.

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Ruđer Bošković Institute, Zagreb, Croatia.
Jožef Stefan Institute, Ljubljana, Slovenia.
Tel Aviv University, Tel Aviv, Israel.
Jožef Stefan Institute, Ljubljana, Slovenia ; University of Nova Gorica, Nova Gorica, Slovenia.


This paper presents homogeneous clusters of patients, identified in the Alzheimer's Disease Neuroimaging Initiative (ADNI) data population of 317 females and 342 males, described by a total of 243 biological and clinical descriptors. Clustering was performed with a novel methodology, which supports identification of patient subpopulations that are homogeneous regarding both clinical and biological descriptors. Properties of the constructed clusters clearly demonstrate the differences between female and male Alzheimer's disease patient groups. The major difference is the existence of two male subpopulations with unexpected values of intracerebral and whole brain volumes.


Alzheimer’s disease; Clustering; Female and male subpopulations

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