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Mediators Inflamm. 2016;2016:3476240. doi: 10.1155/2016/3476240. Epub 2016 Jul 25.

Celecoxib Adjunctive Treatment to Antipsychotics in Schizophrenia: A Review of Randomized Clinical Add-On Trials.

Author information

1
Department of Neurosciences Clinical Imaging, Chair of Psychiatry, "G. d'Annunzio" University, 65100 Chieti, Italy; Polyedra Research Group, 64100 Teramo, Italy.
2
Polyedra Research Group, 64100 Teramo, Italy; NHS, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini", ASL 4, 64100 Teramo, Italy.
3
Department of Neurosciences Clinical Imaging, Chair of Psychiatry, "G. d'Annunzio" University, 65100 Chieti, Italy.
4
Polyedra Research Group, 64100 Teramo, Italy; Villa S. Giuseppe Hospital, Hermanas Hospitalarias, 63100 Ascoli Piceno, Italy; School of Life and Medical Sciences, University of Hertfordshire, Hatfield AL10 9AB, UK.
5
Polyedra Research Group, 64100 Teramo, Italy; Villa S. Giuseppe Hospital, Hermanas Hospitalarias, 63100 Ascoli Piceno, Italy.
6
Polyedra Research Group, 64100 Teramo, Italy.
7
New York State Psychiatric Institute, Columbia University, New York, NY 10027, USA.

Abstract

Schizophrenia is a severe, chronic and debilitating mental disorder. Past literature has reported various hypotheses about the psychopathology of schizophrenia. Recently, a growing literature has been trying to explain the role of inflammation in the etiopathogenesis of schizophrenia. In the past, numerous immune modulation and anti-inflammatory treatment options have been proposed for schizophrenia, but sometimes the results were inconsistent. Electronic search was carried out in November 2015. PubMed and Scopus databases have been used to find studies to introduce in this review. Only randomized-placebo-controlled add-on trials were taken into account. In this way, six articles were obtained for the discussion. Celecoxib showed beneficial effects mostly in early stages of schizophrenia. In chronic schizophrenia, the data are controversial, possibly in part for methodological reasons.

PMID:
27524864
PMCID:
PMC4976163
DOI:
10.1155/2016/3476240
[Indexed for MEDLINE]
Free PMC Article

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