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Int J Epidemiol. 2017 Apr 1;46(2):578-588. doi: 10.1093/ije/dyw186.

Effect of personalized nutrition on health-related behaviour change: evidence from the Food4Me European randomized controlled trial.

Author information

1
Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK.
2
Department of Human Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.
3
Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, UK.
4
UCD Institute of Food and Health, University College Dublin, Dublin, Ireland.
5
Department of Nutrition and Physiology, University of Navarra, Navarra, and CIBER Fisiopatología Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.
6
Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
7
ZIEL Research Center of Nutrition and Food Sciences, Munich Technical University, Munich, Germany.
8
National Food & Nutrition Institute (IZZ), Warsaw, Poland.
9
Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
10
TNO, Microbiology and Systems Biology Group, Zeist, The Netherlands.
11
Eurogenetica Ltd, Burnham-on-Sea, UK.

Abstract

Background:

Optimal nutritional choices are linked with better health, but many current interventions to improve diet have limited effect. We tested the hypothesis that providing personalized nutrition (PN) advice based on information on individual diet and lifestyle, phenotype and/or genotype would promote larger, more appropriate, and sustained changes in dietary behaviour.

Methods:

: Adults from seven European countries were recruited to an internet-delivered intervention (Food4Me) and randomized to: (i) conventional dietary advice (control) or to PN advice based on: (ii) individual baseline diet; (iii) individual baseline diet plus phenotype (anthropometry and blood biomarkers); or (iv) individual baseline diet plus phenotype plus genotype (five diet-responsive genetic variants). Outcomes were dietary intake, anthropometry and blood biomarkers measured at baseline and after 3 and 6 months' intervention.

Results:

At baseline, mean age of participants was 39.8 years (range 18-79), 59% of participants were female and mean body mass index (BMI) was 25.5 kg/m 2 . From the enrolled participants, 1269 completed the study. Following a 6-month intervention, participants randomized to PN consumed less red meat [-5.48 g, (95% confidence interval:-10.8,-0.09), P  = 0.046], salt [-0.65 g, (-1.1,-0.25), P  = 0.002] and saturated fat [-1.14 % of energy, (-1.6,-0.67), P  < 0.0001], increased folate [29.6 µg, (0.21,59.0), P  = 0.048] intake and had higher Healthy Eating Index scores [1.27, (0.30, 2.25), P  = 0.010) than those randomized to the control arm. There was no evidence that including phenotypic and phenotypic plus genotypic information enhanced the effectiveness of the PN advice.

Conclusions:

Among European adults, PN advice via internet-delivered intervention produced larger and more appropriate changes in dietary behaviour than a conventional approach.

KEYWORDS:

Personalized nutrition; diet; genotype; internet-based; metabolic health; obesity; phenotype; randomized controlled trial

PMID:
27524815
DOI:
10.1093/ije/dyw186
[Indexed for MEDLINE]

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