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Ageing Res Rev. 2016 Nov;31:9-35. doi: 10.1016/j.arr.2016.08.004. Epub 2016 Aug 11.

Anti-aging pharmacology: Promises and pitfalls.

Author information

1
D.F. Chebotarev Institute of Gerontology, NAMS, Kiev, Ukraine. Electronic address: vaiserman@geront.kiev.ua.
2
Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine.
3
D.F. Chebotarev Institute of Gerontology, NAMS, Kiev, Ukraine.

Abstract

Life expectancy has grown dramatically in modern times. This increase, however, is not accompanied by the same increase in healthspan. Efforts to extend healthspan through pharmacological agents targeting aging-related pathological changes are now in the spotlight of geroscience, the main idea of which is that delaying of aging is far more effective than preventing the particular chronic disorders. Currently, anti-aging pharmacology is a rapidly developing discipline. It is a preventive field of health care, as opposed to conventional medicine which focuses on treating symptoms rather than root causes of illness. A number of pharmacological agents targeting basic aging pathways (i.e., calorie restriction mimetics, autophagy inducers, senolytics etc.) are now under investigation. This review summarizes the literature related to advances, perspectives and challenges in the field of anti-aging pharmacology.

KEYWORDS:

Age-related pathology; Anti-aging drug; Antioxidant; Calorie restriction mimetic; Healthspan; Lifespan

PMID:
27524412
DOI:
10.1016/j.arr.2016.08.004
[Indexed for MEDLINE]

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