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Mol Cell Endocrinol. 2016 Dec 5;437:120-129. doi: 10.1016/j.mce.2016.08.017. Epub 2016 Aug 11.

Prostaglandin levels, vaginal innervation, and cyst innervation as peripheral contributors to endometriosis-associated vaginal hyperalgesia in rodents.

Author information

1
Department of Anesthesiology, Perioperative, and Pain Medicine, School of Medicine, Stanford University, Stanford, CA, 94305, USA; Program in Neuroscience, Florida State University, Tallahassee, FL, 32306, USA. Electronic address: smcallis@stanford.edu.
2
Program in Neuroscience, Florida State University, Tallahassee, FL, 32306, USA.
3
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IA, 47405, USA.
4
Department of Anesthesiology, Perioperative, and Pain Medicine, School of Medicine, Stanford University, Stanford, CA, 94305, USA.

Abstract

Endometriosis is a painful condition characterized by growth of endometrial cysts outside the uterus. Here, we tested the hypothesis that peripheral innervation and prostaglandin levels contribute to endometriosis-associated pain. Female Sprague-Dawley rats (n = 16) were surgically instrumented by transplanting uterine tissue onto mesenteric arteries within the peritoneal cavity to create a model of endometriosis which forms extra-uterine endometrial cysts and vaginal hyperalgesia. Our results describe a significant positive correlation between endometriosis-induced vaginal hyperalgesia and cyst innervation density (sensory, r = 0.70, p = 0.003; sympathetic, r = 0.55, p = 0.03), vaginal canal sympathetic innervation density (r = 0.80, p = 0.003), and peritoneal fluid levels of the prostaglandins PGE2 (r = 0.65, p = 0.01) and PGF2α (r = 0.63, p = 0.02). These results support the involvement of cyst innervation and prostaglandins in endometriosis-associated pain. We also describe how sympathetic innervation density of the vaginal canal is an important predictor of vaginal hyperalgesia.

KEYWORDS:

Cyst; Endometriosis; Innervation; Pelvic pain; Prostaglandin; Vaginal hyperalgesia

PMID:
27524411
PMCID:
PMC5048574
DOI:
10.1016/j.mce.2016.08.017
[Indexed for MEDLINE]
Free PMC Article

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