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Bioanalysis. 2016 Sep;8(17):1777-91. doi: 10.4155/bio-2016-0073. Epub 2016 Aug 15.

Determination of endocrine-disrupting chemicals in human milk by dispersive liquid-liquid microextraction.

Author information

1
Instituto de Investigación Biosanitaria (ibs. GRANADA), Hospitales Universitarios de Granada, Granada, Spain.
2
CIBER en Epidemiología y Salud Pública (CIBERESP), Granada, Spain.
3
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía. Parque Tecnológico de Ciencias de la Salud, Av del Conocimiento, 34, 18016 Armilla, Granada, Spain.
4
Departamento de Radiología y Medicina Física, Universidad de Granada, Granada, Spain.

Abstract

AIM:

Human populations are widely exposed to numerous so-called endocrine-disrupting chemicals, exogenous compounds able to interfere with the endocrine system. This exposure has been associated with several health disorders. New analytical procedures are needed for biomonitoring these xenobiotics in human matrices. A quick and inexpensive methodological procedure, based on sample treatment by dispersive liquid-liquid microextraction, is proposed for the determination of bisphenols, parabens and benzophenones in samples.

RESULTS:

LOQs ranged from 0.4 to 0.7 ng ml(-1) and RSDs from 4.3 to 14.8%.

CONCLUSION:

This methodology was satisfactorily applied in the simultaneous determination of a wide range of endocrine-disrupting chemicals in human milk samples and is suitable for application in biomonitoring studies.

KEYWORDS:

dispersive liquid–liquid microextraction; endocrine-disrupting chemicals; human milk

PMID:
27523983
DOI:
10.4155/bio-2016-0073
[Indexed for MEDLINE]

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