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Exp Gerontol. 2016 Oct;83:112-9. doi: 10.1016/j.exger.2016.08.005. Epub 2016 Aug 11.

Effect of creatine supplementation and drop-set resistance training in untrained aging adults.

Author information

1
Faculty of Kinesiology and Health Studies, University of Regina, Canada.
2
Faculty of Kinesiology and Health Studies, University of Regina, Canada. Electronic address: Darren.Candow@uregina.ca.
3
College of Pharmacy and Nutrition, University of Saskatchewan, Canada.

Abstract

OBJECTIVE:

To investigate the effects of creatine supplementation and drop-set resistance training in untrained aging adults. Participants were randomized to one of two groups: Creatine (CR: n=14, 7 females, 7 males; 58.0±3.0yrs, 0.1g/kg/day of creatine+0.1g/kg/day of maltodextrin) or Placebo (PLA: n=17, 7 females, 10 males; age: 57.6±5.0yrs, 0.2g/kg/day of maltodextrin) during 12weeks of drop-set resistance training (3days/week; 2 sets of leg press, chest press, hack squat and lat pull-down exercises performed to muscle fatigue at 80% baseline 1-repetition maximum [1-RM] immediately followed by repetitions to muscle fatigue at 30% baseline 1-RM).

METHODS:

Prior to and following training and supplementation, assessments were made for body composition, muscle strength, muscle endurance, tasks of functionality, muscle protein catabolism and diet.

RESULTS:

Drop-set resistance training improved muscle mass, muscle strength, muscle endurance and tasks of functionality (p<0.05). The addition of creatine to drop-set resistance training significantly increased body mass (p=0.002) and muscle mass (p=0.007) compared to placebo. Males on creatine increased muscle strength (lat pull-down only) to a greater extent than females on creatine (p=0.005). Creatine enabled males to resistance train at a greater capacity over time compared to males on placebo (p=0.049) and females on creatine (p=0.012). Males on creatine (p=0.019) and females on placebo (p=0.014) decreased 3-MH compared to females on creatine.

CONCLUSIONS:

The addition of creatine to drop-set resistance training augments the gains in muscle mass from resistance training alone. Creatine is more effective in untrained aging males compared to untrained aging females.

KEYWORDS:

Endurance; Muscle mass; Muscle protein catabolism; Sarcopenia; Strength

PMID:
27523919
DOI:
10.1016/j.exger.2016.08.005
[Indexed for MEDLINE]

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