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J Infect Dis. 2016 Oct 15;214(suppl 3):S275-S280. Epub 2016 Aug 11.

Ebola Virus Disease Is Characterized by Poor Activation and Reduced Levels of Circulating CD16+ Monocytes.

Author information

1
Heinrich Pette Institute, Leibniz Institute for Experimental Virology Department of Virology The European Mobile Laboratory Consortium, Bernhard Nocht Institute for Tropical Medicine, Hamburg German Center for Infection Research, Partner Site Hamburg.
2
Department of Virology The European Mobile Laboratory Consortium, Bernhard Nocht Institute for Tropical Medicine, Hamburg German Center for Infection Research, Partner Site Hamburg.
3
Heinrich Pette Institute, Leibniz Institute for Experimental Virology.
4
Department of Virology German Center for Infection Research, Partner Site Hamburg.
5
Hannover Medical School.
6
Institute of Experimental Virology, Twincore, Center for Experimental and Clinical Infection Research, Hannnover, Germany.
7
Department of Microbiology and Immunology, Stanford University School of Medicine, California.
8
Université Gamal Abdel Nasser de Conakry, Laboratoire des Fièvres Hémorragiques en Guinée, Conakry, Guinea.

Abstract

A number of previous studies have identified antigen-presenting cells (APCs) as key targets of Ebola virus (EBOV), but the role of APCs in human Ebola virus disease (EVD) is not known. We have evaluated the phenotype and kinetics of monocytes, neutrophils, and dendritic cells (DCs) in peripheral blood of patients for whom EVD was diagnosed by the European Mobile Laboratory in Guinea. Acute EVD was characterized by reduced levels of circulating nonclassical CD16+ monocytes with a poor activation profile. In survivors, CD16+ monocytes were activated during recovery, coincident with viral clearance, suggesting an important role of this cell subset in EVD pathophysiology.

KEYWORDS:

CD14; CD16; Ebola virus; Ebola virus disease; monocytes

PMID:
27521367
DOI:
10.1093/infdis/jiw260
[Indexed for MEDLINE]

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