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J Infect Dis. 2016 Nov 1;214(9):1357-1360. Epub 2016 Aug 11.

Zika Virus-Induced Antibody Response Enhances Dengue Virus Serotype 2 Replication In Vitro.

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Department of Pathobioloigcal Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge.


Zika virus has emerged in the Americas, where dengue virus is endemic. Among the 4 serotypes of dengue virus, antibody-dependent enhancement is thought to enhance viral replication and disease severity. Reports suggest that anti-dengue virus antibody may enhance Zika virus replication. We investigated whether Zika virus antibodies enhance dengue virus replication, by exposing C57Bl/6 mice to Zika virus. Polyclonal serum was verified for strong Zika virus-neutralizing, dengue virus-subneutralizing capacity. Then we determined the enhancement capabilities of Zika virus-immune serum for dengue virus in vitro. We showed that Zika virus antibodies have the ability to enhance dengue virus infections, which is important, because in many Zika virus-affected areas, dengue virus is expected to remain endemic.


Zika; antibody; antibody dependent enhancement; dengue; enhancement; plaque reduction neutralization test (PRNT)

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