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Biochem Pharmacol. 1989 Jul 15;38(14):2259-62.

Inverse stereoselectivity in the binding of acenocoumarol to human serum albumin and to alpha 1-acid glycoprotein.

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1
Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.

Abstract

Stereoselective binding of rac-acenocoumarol to human serum albumin (HSA) and alpha 1-acid glycoprotein (alpha 1-AGP) was investigated by affinity chromatography and by combined ultrafiltration (UF) and circular dichroism (CD) methods. For HSA, the ratio of the enantiomeric constants was KR/KS = 2, while for alpha 1-AGP, KS/KR = 3.

PMID:
2751692
[Indexed for MEDLINE]
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