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Front Synaptic Neurosci. 2016 Jul 28;8:20. doi: 10.3389/fnsyn.2016.00020. eCollection 2016.

The Emergence of NMDA Receptor Metabotropic Function: Insights from Imaging.

Author information

1
Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California at San Diego San Diego, CA, USA.
2
Genome Institute of Singapore Singapore, Singapore.

Abstract

The NMDA receptor (R) participates in many important physiological and pathological processes. For example, its activation is required for both long-term potentiation (LTP) and long-term depression (LTD) of synaptic transmission, cellular models of learning and memory. Furthermore, it may play a role in the actions of amyloid-beta on synapses as well as in the signaling leading to cell death following stroke. Until recently, these processes were thought to be mediated by ion-flux through the receptor. Using a combination of imaging and electrophysiological approaches, ion-flux independent functions of the NMDAR were recently examined. In this review, we will discuss the role of metabotropic NMDAR function in LTD and synaptic dysfunction.

KEYWORDS:

FRET-FLIM; NMDAR interactions with CaMKII; PP1; amyloid-beta induced depression; excitotoxicity; ion-flux independent; long-term depression (LTD)

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