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Front Synaptic Neurosci. 2016 Jul 28;8:20. doi: 10.3389/fnsyn.2016.00020. eCollection 2016.

The Emergence of NMDA Receptor Metabotropic Function: Insights from Imaging.

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Center for Neural Circuits and Behavior, Department of Neuroscience and Section for Neurobiology, Division of Biology, University of California at San Diego San Diego, CA, USA.
Genome Institute of Singapore Singapore, Singapore.


The NMDA receptor (R) participates in many important physiological and pathological processes. For example, its activation is required for both long-term potentiation (LTP) and long-term depression (LTD) of synaptic transmission, cellular models of learning and memory. Furthermore, it may play a role in the actions of amyloid-beta on synapses as well as in the signaling leading to cell death following stroke. Until recently, these processes were thought to be mediated by ion-flux through the receptor. Using a combination of imaging and electrophysiological approaches, ion-flux independent functions of the NMDAR were recently examined. In this review, we will discuss the role of metabotropic NMDAR function in LTD and synaptic dysfunction.


FRET-FLIM; NMDAR interactions with CaMKII; PP1; amyloid-beta induced depression; excitotoxicity; ion-flux independent; long-term depression (LTD)

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