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AJNR Am J Neuroradiol. 2016 Dec;37(12):2407-2409. Epub 2016 Aug 11.

In Vivo Monitoring of Rat Spinal Cord Metabolism Using Hyperpolarized Carbon-13 MR Spectroscopic Imaging.

Author information

1
From the Department of Radiology and Biomedical Imaging (I.P., S.J.N., J.F.T.) ilwoo.park@ucsf.edu.
2
From the Department of Radiology and Biomedical Imaging (I.P., S.J.N., J.F.T.).
3
Department of Bioengineering and Therapeutic Sciences (S.J.N.).
4
Brain and Spinal Injury Center (BASIC), San Francisco General Hospital (J.F.T.), University of California, San Francisco, San Francisco, California.

Abstract

This study demonstrated the feasibility of using hyperpolarized 13C-MR spectroscopic imaging with [1-13C]-pyruvate to evaluate in vivo spinal cord metabolism. High pyruvate and relatively small lactate signal were observed in the cervical spinal cords of naive rats. Lactate and pyruvate measures were similar for spinal cord and supratentorial brain. The results from this study establish baseline measures for spinal cord hyperpolarized MRS imaging with 13C pyruvate. This technique holds promise as a valuable molecular imaging tool for monitoring biochemical processes in the normal and diseased spinal cord.

PMID:
27516238
PMCID:
PMC5161558
DOI:
10.3174/ajnr.A4920
[Indexed for MEDLINE]
Free PMC Article

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