Format

Send to

Choose Destination
Arch Pharm Res. 2016 Aug;39(8):1137-43. doi: 10.1007/s12272-016-0780-2. Epub 2016 Aug 12.

Attenuation of Aβ toxicity by promotion of mitochondrial fusion in neuroblastoma cells by liquiritigenin.

Author information

1
Graduate School of East-West Medical Science, Kyung Hee University, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea.
2
Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Science, Seoul, 01812, Republic of Korea.
3
Department of Genetic Engineering, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, 16356, Republic of Korea.
4
Graduate School of East-West Medical Science, Kyung Hee University, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea. shinarago@khu.ac.kr.
5
Graduate School of East-West Medical Science, Kyung Hee University, 1732, Deogyeong-daero, Giheung-gu, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea. shinarago@khu.ac.kr.
6
Graduate School of East-West Medical Science, Kyung Hee University, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea. dhcho@khu.ac.kr.
7
Graduate School of East-West Medical Science, Kyung Hee University, 1732, Deogyeong-daero, Giheung-gu, Yongin-Si, Gyeonggi-Do, 17104, Republic of Korea. dhcho@khu.ac.kr.

Abstract

Mitochondrial dynamics control mitochondrial morphology and function, and aberrations in these are associated with various neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. To identify novel regulators of mitochondrial dynamics, we screened a phytochemical library and identified liquiritigenin as a potent inducer of mitochondrial fusion. Treatment with liquiritigenin induced an elongated mitochondrial morphology in SK-N-MC cells. In addition, liquiritigenin rescued mitochondrial fragmentation induced by knockout of mitochondrial fusion mediators such as Mfn1, Mfn2, and Opa1. Furthermore, we found that treatment with liquiritigenin notably inhibited mitochondrial fragmentation and cytotoxicity induced by Aβ in SK-N-MC cells.

KEYWORDS:

Amyloid beta; Fusion/fission; Liquiritigenin; Mitochondria dynamics

PMID:
27515055
DOI:
10.1007/s12272-016-0780-2
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center