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Arch Pharm Res. 2016 Aug;39(8):1100-13. doi: 10.1007/s12272-016-0809-6. Epub 2016 Aug 11.

Myofibroblasts and inflammatory cells as players of cardiac fibrosis.

Author information

1
Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. hikurose@phar.kyushu-u.ac.jp.
2
Department of Pharmacology, Faculty of Pharmacy, Mahidol University, Bangkok, 10400, Thailand.

Abstract

On myocardial infarction, many cells are injured or died owing to arterial occlusion. Intracellular molecules released from injured or dead cells initiate inflammatory responses that play important roles in cardiac remodeling including fibrosis. Fibrosis is an excess accumulation of extracellular collagen. Currently, drugs used to treat cardiac fibrosis are not commercially available. Myofibroblasts are responsible for the production and secretion of collagen. Infiltrating inflammatory cells interact with fibroblasts or other cells and promote myofibroblast formation. Inflammatory cells also modulate the activities of myofibroblasts. Regulation of collagen production is critical for modulating the progression of fibrosis. Hence, the manipulation of activities of inflammatory cells and myofibroblasts will provide promising therapeutic targets for treatment of cardiac fibrosis.

KEYWORDS:

Cardiac fibrosis; Inflammation; Myocardial infarction; Myofibroblasts; Signaling molecules

PMID:
27515051
DOI:
10.1007/s12272-016-0809-6
[Indexed for MEDLINE]

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