Send to

Choose Destination
Clin Chest Med. 2016 Sep;37(3):475-86. doi: 10.1016/j.ccm.2016.04.010. Epub 2016 Jun 25.

Birt-Hogg-Dubé Syndrome.

Author information

Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, 231 Albert Sabin Way, MSB Room 6053, ML 0564, Cincinnati, OH 45267, USA. Electronic address:
Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, 2330 Post Street, Room 420, San Francisco, CA 94115, USA.
Department of Pulmonary Medicine, Cleveland Clinic, 9500 Euclid Avenue A90, Cleveland, OH 44195, USA.


Birt-Hogg-Dubé syndrome (BHD) is a rare autosomal dominant disorder caused by mutations in the Folliculin gene and is characterized by the formation of fibrofolliculomas, early onset renal cancers, pulmonary cysts, and spontaneous pneumothoraces. The exact pathogenesis of tumor and lung cyst formation in BHD remains unclear. There is great phenotypic variability in the clinical features of BHD, and patients can present with any combination of skin, pulmonary, or renal findings. More than 80% of adult patients with BHD have pulmonary cysts on high-resolution computed tomography scan of the chest.


Birt-Hogg-Dubé syndrome; Diffuse cystic lung disease; Fibrofolliculomas; Folliculin; Pleurodesis; Pneumothorax; Renal cancer

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center