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Turk J Med Sci. 2016 Feb 17;46(2):524-38. doi: 10.3906/sag-1411-6.

Comparison between the protective effects of vitamin K and vitamin A on the modulation of hypervitaminosis D3 short-term toxicity in adult albino rats.

Author information

1
Department of Forensic Medicine and Clinical Toxicology, College of Medicine, Suez Canal University, Ismaileya, Egypt.
2
Department of Anatomy, College of Medicine, Al-Azhar University, Cairo, Egypt.
3
Department of Pathology, College of Medicine, University of Sadat City, Sadat City, Egypt.
4
Department of Microbiology, College of Medicine, Taif University, Taif, Saudi Arabia.

Abstract

BACKGROUND/AIM:

Vitamin D3 has increased risk of toxicity due to its common use in multivitamin preparations. Vitamin K and vitamin A play an important role in vitamin D action. The goal of the current study was to compare the protective effects of vitamin K and vitamin A on the modulation of hypervitaminosis D3 toxicity in rats by assessing serum calcium, renal function tests, cardiac enzymes, and related histopathological changes.

MATERIALS AND METHODS:

Eighty adult albino rats were divided into four groups; each group consisted of 20 rats. The first group received water; the second received a toxic dose of vitamin D3; the third received a toxic dose of vitamin D3 with vitamin A; and the fourth received a toxic dose of vitamin D3 with vitamin K.

RESULTS:

Vitamin D3 toxicity led to significant abnormalities of cardiac enzymes, renal function tests, and serum calcium associated with histopathological changes in the kidney, heart, lung, adrenal gland, and aorta. Individual administration of vitamin A or vitamin K with a toxic dose of vitamin D improved the biochemical and histopathological abnormalities of hypervitaminosis D3.

CONCLUSION:

Vitamins A and K showed the same protective effects in the modulation of hypervitaminosis D3 short-term toxicity.

KEYWORDS:

Vitamin D3; hypervitaminosis; vitamin A; vitamin K

PMID:
27511521
DOI:
10.3906/sag-1411-6
[Indexed for MEDLINE]

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