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Turk J Med Sci. 2016 Jan 5;46(1):194-202. doi: 10.3906/sag-1411-35.

Apitherapy products enhance the recovery of CCL4-induced hepatic damages in rats.

Author information

1
Department of Nutrition and Dietetics, College of Health, Recep Tayyip Erdoğan University, Rize, Turkey.
2
Maçka Vocational School, Karadeniz Technical University, Trabzon, Turkey.
3
Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey.
4
Department of Histology and Embryology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
5
Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
6
Department of Molecular Biology and Genetics, Faculty of Sciences, Canik Başarı University, Samsun, Turkey.
7
Department of Chemistry, Faculty of Sciences, Karadeniz Technical University, Trabzon, Turkey.

Abstract

BACKGROUND/AIM:

Our objective was to identify the antioxidant properties of honeybee products from Turkey, chestnut honey, pollen, propolis, and royal jelly, and their hepatoprotective activity against CCl4-induced hepatic damage in rats.

MATERIALS AND METHODS:

Animals were fed with honeybee products for 7 days following CCl4 injection. Development of liver damage and oxidative stress were monitored by measuring the activities of the enzymes alanine transaminase, aspartate transaminase, malondialdehyde, superoxide dismutase, and catalase. Antioxidant capacities of the bee products were identified using FRAP and DPPH assays, as well as by measuring total phenolic and flavonoid contents.

RESULTS:

The antioxidant activities of the honeybee products were highest in propolis, followed, in order, by pollen, honey, and royal jelly. Despite their different levels of antioxidant capacity, their roles in the prevention of liver damage induced by CCl4 were very similar, which can be explained through their bioavailability to the treated animals.

CONCLUSIONS:

Our results suggest that honey, propolis, pollen, and royal jelly significantly enhanced the healing of CCl4-induced liver damage, partially due to their antioxidant properties and bioavailability.

KEYWORDS:

Liver damage; apitherapy; honey; pollen; propolis; royal jelly

PMID:
27511354
DOI:
10.3906/sag-1411-35
[Indexed for MEDLINE]

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