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Nat Rev Neurosci. 2016 Oct;17(10):611-22. doi: 10.1038/nrn.2016.100. Epub 2016 Aug 11.

The cellular mechanisms that maintain neuronal polarity.

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The Jungers Center for Neurosciences Research, Oregon Health &Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.


As polarized cells, neurons maintain different sets of resident plasma membrane proteins in their axons and dendrites, which is consistent with the different roles that these neurites have in electrochemical signalling. Axonal and dendritic proteins are synthesized together within the somatodendritic domain; this raises a fundamental question: what is the nature of the intracellular trafficking machinery that ensures that these proteins reach the correct domain? Recent studies have advanced our understanding of the processes underlying the selective sorting and selective transport of axonal and dendritic proteins and have created potential avenues for future progress.

[Indexed for MEDLINE]

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