Format

Send to

Choose Destination
J Neurosci. 2016 Aug 10;36(32):8390-8. doi: 10.1523/JNEUROSCI.4432-15.2016.

BDNF Val66Met Polymorphism Interacts with Sleep Consolidation to Predict Ability to Create New Declarative Memories.

Author information

1
Center for Advanced Research in Sleep Medicine and Research Center, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, H4J 1C5, Canada, Departments of Psychology, nadia.gosselin@umontreal.ca.
2
Center for Advanced Research in Sleep Medicine and Research Center, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, H4J 1C5, Canada, Department of Psychology, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, G9A 5H7, Canada.
3
Center for Advanced Research in Sleep Medicine and Research Center, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, H4J 1C5, Canada, Department of Psychology, Université du Québec à Montréal, Montreal, Québec, H3C 3P8, Canada.
4
Center for Advanced Research in Sleep Medicine and Research Center, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, H4J 1C5, Canada, Psychiatry, and.
5
Center for Advanced Research in Sleep Medicine and Research Center, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, H4J 1C5, Canada, Neuroscience, Université de Montréal, Montréal, Québec, H3C 3J7, Canada.
6
Center for Advanced Research in Sleep Medicine and Research Center, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, H4J 1C5, Canada.
7
Centre for Studies on Prevention of Alzheimer's Disease, Douglas Institute, Verdun, Québec, H4H 1R3, Canada, and Department of Psychiatry and Medicine, McGill University, Montréal, Québec, H3A 0G4, Canada.
8
Center for Advanced Research in Sleep Medicine and Research Center, Hôpital du Sacré-Coeur de Montréal, Montréal, Québec, H4J 1C5, Canada, Departments of Psychology.

Abstract

It is hypothesized that a fundamental function of sleep is to restore an individual's day-to-day ability to learn and to constantly adapt to a changing environment through brain plasticity. Brain-derived neurotrophic factor (BDNF) is among the key regulators that shape brain plasticity. However, advancing age and carrying the BDNF Met allele were both identified as factors that potentially reduce BDNF secretion, brain plasticity, and memory. Here, we investigated the moderating role of BDNF polymorphism on sleep and next-morning learning ability in 107 nondemented individuals who were between 55 and 84 years of age. All subjects were tested with 1 night of in-laboratory polysomnography followed by a cognitive evaluation the next morning. We found that in subjects carrying the BDNF Val66Val polymorphism, consolidated sleep was associated with significantly better performance on hippocampus-dependent episodic memory tasks the next morning (β-values from 0.290 to 0.434, p ≤ 0.01). In subjects carrying at least one copy of the BDNF Met allele, a more consolidated sleep was not associated with better memory performance in most memory tests (β-values from -0.309 to -0.392, p values from 0.06 to 0.15). Strikingly, increased sleep consolidation was associated with poorer performance in learning a short story presented verbally in Met allele carriers (β = -0.585, p = 0.005). This study provides new evidence regarding the interacting roles of consolidated sleep and BDNF polymorphism in the ability to learn and stresses the importance of considering BDNF polymorphism when studying how sleep affects cognition.

SIGNIFICANCE STATEMENT:

Individuals with the BDNF Val/Val (valine allele) polymorphism showed better memory performance after a night of consolidated sleep. However, we observed that middle-aged and older individuals who are carriers of the BDNF Met allele displayed no positive association between sleep quality and their ability to learn the next morning. This interaction between sleep and BDNF polymorphism was more salient for hippocampus-dependent tasks than for other cognitive tasks. Our results support the hypothesis that reduced activity-dependent secretion of BDNF impairs the benefits of sleep on synaptic plasticity and next-day memory. Our work advances the field by revealing new evidence of a clear genetic heterogeneity in how sleep consolidation contributes to the ability to learn.

KEYWORDS:

aging; brain derived neurotrophic factor; cognition; memory; sleep; slow-wave sleep

PMID:
27511011
PMCID:
PMC5811258
DOI:
10.1523/JNEUROSCI.4432-15.2016
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center