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Clin Transl Med. 2016 Dec;5(1):27. doi: 10.1186/s40169-016-0112-7. Epub 2016 Aug 10.

Therapeutic potential of mesenchymal stem cell based therapy for osteoarthritis.

Author information

1
Department of Orthopedics, Georgia Regents University, Augusta, GA, USA.
2
Department of Pathology, Georgia Regents University, Augusta, GA, USA.
3
Institute of Regenerative and Reparative Medicine, Georgia Regents University, Augusta, GA, USA.
4
Department of Cell Biology and Anatomy, Georgia Regents University, Augusta, GA, USA.
5
Department of Orthopedics, Georgia Regents University, Augusta, GA, USA. sfulzele@augusta.edu.
6
Institute of Regenerative and Reparative Medicine, Georgia Regents University, Augusta, GA, USA. sfulzele@augusta.edu.
7
Department of Orthopedics Surgery, Augusta University, Augusta, GA, 30904, USA. sfulzele@augusta.edu.

Abstract

Osteoarthritis (OA) is a chronic degenerative disease affecting articular cartilage in joints, and it is a leading cause of disability in the United States. Current pharmacological treatment strategies are ineffective to prevent the OA progression; however, cellular therapies have the potential to regenerate the lost cartilage, combat cartilage degeneration, provide pain relief, and improve patient mobility. One of the most promising sources of cellular regenerative medicine is from mesenchymal stem cells (MSCs). MSCs can be isolated from adipose tissue, bone marrow, synovial tissue, and other sources. The aim of this review is to compile recent advancement in cellular based therapy more specifically in relation to MSCs in the treatment of osteoarthritis.

KEYWORDS:

ADSC; Cell therapy; Osteoarthritis; Stem cell

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