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  • PMID: 27509252 was deleted because it is a duplicate of PMID: 27741032
J Acquir Immune Defic Syndr. 2016 Nov 1;73(3):e46-e50.

Implementation and Operational Research: Population-Based Active Tuberculosis Case Finding During Large-Scale Mobile HIV Testing Campaigns in Rural Uganda.

Author information

1
*Makerere University-University of California, San Francisco Research Collaboration, Kampala, Uganda; †Division of HIV, Infectious Diseases and Global Medicine, University of California San Francisco, San Francisco, CA; ‡Center for AIDS Prevention Studies, Department of Medicine, University of California San Francisco (UCSF), San Francisco, CA; §University of California Berkeley School of Public Health, Berkeley, CA; and ‖Department of Medicine, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.

Abstract

BACKGROUND:

Active tuberculosis (TB) screening outside clinics and in communities may reduce undiagnosed TB.

METHODS:

To determine the yield of TB screening during community-based HIV testing campaigns (CHC) in 7 rural Ugandan communities within an ongoing cluster-randomized trial of universal HIV testing and treatment (SEARCH, NCT:01864603), we offered sputum microscopy to participants with prolonged cough (>2 weeks). We determined the number of persons needed to screen to identify one TB case, and the number of cases identified that linked to clinic and completed TB treatment.

RESULTS:

Of 36,785 adults enumerated in 7 communities, 27,214 (74%) attended CHCs, and HIV testing uptake was >99%, with 941 (3.5%) HIV-infected adults identified. Five thousand seven hundred eighty-six adults (21%) reported cough and 2876 (11%) reported cough >2 weeks. Staff obtained sputum in 1099/2876 (38%) participants with prolonged cough and identified 10 adults with AFB-positive sputum; 9 new diagnoses and 1 known case already under treatment. The number needed to screen to identify one new TB case was 3024 adults overall: 320 adults with prolonged cough and 80 HIV-infected adults with prolonged cough. All 9 newly diagnosed AFB+ participants were linked to TB care within 2 weeks and were initiated TB treatment.

CONCLUSIONS:

In a rural Ugandan setting, TB screening as an adjunct to large-scale mobile HIV testing campaigns provides an opportunity to increase TB case detection.

PMID:
27741032
DOI:
10.1097/QAI.0000000000001142
[Indexed for MEDLINE]

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