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Horm Mol Biol Clin Investig. 2016 Nov 1;28(2):85-94. doi: 10.1515/hmbci-2016-0015.

Pituitary-bone connection in skeletal regulation.

Abstract

Pituitary hormones have traditionally been thought to exert specific, but limited function on target tissues. More recently, the discovery of these hormones and their receptors in organs such as the skeleton suggests that pituitary hormones have more ubiquitous functions. Here, we discuss the interaction of growth hormone (GH), follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), adrenocorticotrophic hormone (ACTH), prolactin, oxytocin and arginine vasopressin (AVP) with bone. The direct skeletal action of pituitary hormones therefore provides new insights and therapeutic opportunities for metabolic bone diseases, prominently osteoporosis.

PMID:
27508964
DOI:
10.1515/hmbci-2016-0015
[Indexed for MEDLINE]

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