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Cell Metab. 2016 Aug 9;24(2):210-22. doi: 10.1016/j.cmet.2016.07.014.

Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0): Recommendations for Standardized FDG-PET/CT Experiments in Humans.

Author information

1
National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: kong.chen@nih.gov.
2
National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: aaron.cypess@nih.gov.
3
National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: maren.laughlin@nih.gov.
4
National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
5
Phoenix Children's Hospital, Phoenix, AZ 85016, USA.
6
Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
7
Göteborg University, 405 30 Göteborg, Sweden.
8
University of Washington, Seattle, WA 98105, USA.
9
Maastricht University, 6211 LK Maastricht, Netherlands.
10
National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
11
University of Iowa, Iowa City, IA 52242, USA.
12
Turku University Hospital, 20500 Turku, Finland; University of Turku, 20500 Turku, Finland.
13
Washington University School of Medicine, Mallinckrodt Institute of Radiology, Saint Louis, MO 63110, USA.

Abstract

Human brown adipose tissue (BAT) presence, metabolic activity, and estimated mass are typically measured by imaging [18F]fluorodeoxyglucose (FDG) uptake in response to cold exposure in regions of the body expected to contain BAT, using positron emission tomography combined with X-ray computed tomography (FDG-PET/CT). Efforts to describe the epidemiology and biology of human BAT are hampered by diverse experimental practices, making it difficult to directly compare results among laboratories. An expert panel was assembled by the National Institute of Diabetes and Digestive and Kidney Diseases on November 4, 2014 to discuss minimal requirements for conducting FDG-PET/CT experiments of human BAT, data analysis, and publication of results. This resulted in Brown Adipose Reporting Criteria in Imaging STudies (BARCIST 1.0). Since there are no fully validated best practices at this time, panel recommendations are meant to enhance comparability across experiments, but not to constrain experimental design or the questions that can be asked.

PMID:
27508870
PMCID:
PMC4981083
DOI:
10.1016/j.cmet.2016.07.014
[Indexed for MEDLINE]
Free PMC Article

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