Robotic and open distal pancreatectomy with celiac axis resection for locally advanced pancreatic body tumors: a single institutional assessment of perioperative outcomes and survival

HPB (Oxford). 2016 Oct;18(10):835-842. doi: 10.1016/j.hpb.2016.05.003. Epub 2016 Jul 8.

Abstract

Background: Distal pancreatectomy with celiac axis resection (DP-CAR) is an option for T4 tumors of the pancreatic body. We examined the perioperative and oncologic outcomes of open and robotic DP-CAR at a high-volume pancreatic center.

Methods: Retrospective review of all consecutive DP-CARs. Patient demographics, 90-day perioperative outcomes, and disease specific survival were collected.

Results: 30 DP-CARs were performed (11 Robotic, 19 Open). Both groups had similar preoperative/tumor characteristics, and 27 of 28 PDA patients received neoadjuvant chemotherapy. Robotic DP-CAR was associated with decreased OT (316 vs. 476 min), reduced EBL (393 vs. 1736 ml) and lower rates of blood transfusion (0% vs. 54%) (all p < 0.05). No robotic DP-CAR required conversion. Both groups had similar rates of 90-day mortality, major morbidity, LOS, readmission, and receipt of adjuvant therapy. Similarly, both approaches were associated with high R0 resection rates (82% vs. 79%). At a median follow-up of 33 months, median overall survival for the PDA cohort was 35 months, with no difference in the robotic and open approach (33 and 40 months, p = 0.310).

Conclusions: With a median survival approaching 3 years, DP-CAR represents an effective treatment for select patients with locally advanced pancreatic body cancer, regardless of approach.

Publication types

  • Comparative Study
  • Video-Audio Media

MeSH terms

  • Aged
  • Blood Transfusion
  • Carcinoma, Pancreatic Ductal / mortality
  • Carcinoma, Pancreatic Ductal / pathology
  • Carcinoma, Pancreatic Ductal / surgery*
  • Celiac Artery / surgery*
  • Chemotherapy, Adjuvant
  • Female
  • Hospitals, High-Volume
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Margins of Excision
  • Middle Aged
  • Neoadjuvant Therapy
  • Neoplasm Staging
  • Neoplasm, Residual
  • Operative Time
  • Pancreatectomy / adverse effects
  • Pancreatectomy / methods*
  • Pancreatectomy / mortality
  • Pancreatic Neoplasms / mortality
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / surgery*
  • Pennsylvania
  • Postoperative Complications / etiology
  • Retrospective Studies
  • Risk Factors
  • Robotic Surgical Procedures / adverse effects
  • Robotic Surgical Procedures / methods*
  • Robotic Surgical Procedures / mortality
  • Time Factors
  • Treatment Outcome