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Phytochemistry. 2016 Oct;130:335-42. doi: 10.1016/j.phytochem.2016.08.001. Epub 2016 Aug 6.

Eudesmane-type sesquiterpenoids from Salvia plebeia inhibit IL-6-induced STAT3 activation.

Author information

1
Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, South Korea; College of Pharmacy, Chungnam National University, Daejeon 34134, South Korea.
2
Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, South Korea.
3
College of Pharmacy, Chungnam National University, Daejeon 34134, South Korea.
4
Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, South Korea. Electronic address: lswdoc@kribb.re.kr.
5
Natural Product Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, South Korea. Electronic address: rho-m@kribb.re.kr.

Abstract

Seven eudesmane-type sesquiterpenoid lactones and the known plebeiolide C were isolated from an ethanol-soluble extract of the aerial parts of Salvia plebeia R. Br. Their structures were determined via NMR and MS, and their absolute configurations were elucidated using ECD, and X-ray crystallographic analysis, as well as the modified Mosher ester method. All isolates were evaluated for their inhibitory effects on IL6-induced STAT3 promoter activation in stably transfected Hep3B cells. Of these isolates, eudebeiolide D exhibited an inhibitory effect with the IC50 value of 1.1 μM.

KEYWORDS:

Eudesmane sesquiterpenoids; IL-6; Inflammation; Lamiaceae; STAT3; Salvia plebeia

PMID:
27506573
DOI:
10.1016/j.phytochem.2016.08.001
[Indexed for MEDLINE]

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