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Cancer Cell. 2016 Aug 8;30(2):194-196. doi: 10.1016/j.ccell.2016.07.010.

Sticking It to Cancer with Molecular Glue for SHP2.

Author information

1
Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA.
2
Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY 10016, USA. Electronic address: benjamin.neel@nyumc.org.

Abstract

Much effort has been expended to develop inhibitors against protein-tyrosine phosphatases (PTPs), nearly all of it unsuccessful. A recent report, describing a highly specific, orally bioavailable inhibitor of the PTP oncoprotein SHP2 with in vivo activity, suggests that allostery might provide a way forward for PTP inhibitor development.

PMID:
27505669
PMCID:
PMC5558882
DOI:
10.1016/j.ccell.2016.07.010
[Indexed for MEDLINE]
Free PMC Article

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