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J Cell Sci. 2016 Aug 1;129(15):2887-96. doi: 10.1242/jcs.188904. Epub 2016 Jul 11.

Regulation of myogenesis by environmental hypoxia.

Author information

1
Université Paris13 Sorbonne Paris Cité, EA2363, UFR-SMBH, Laboratoire Hypoxie et poumons, Bobigny 93017, Cedex, France mbeaudry@yahoo.fr thierry.darribere@upmc.fr.
2
Université Paris13 Sorbonne Paris Cité, EA2363, UFR-SMBH, Laboratoire Hypoxie et poumons, Bobigny 93017, Cedex, France UPMC Sorbonne Universités (Université Pierre et Marie Curie), UMR CNRS 7622, Laboratoire de Biologie du Développement, Paris 75252, Cedex 05, France.
3
Université Paris-Descartes Sorbonne Paris cité, 75015 Paris, France Université d'Evry, Unité de Biologie Intégrative Appliquée à l'Exercice EA 7372, 9100 Evry, France.
4
UPMC Sorbonne Universités (Université Pierre et Marie Curie), UMR CNRS 7622, Laboratoire de Biologie du Développement, Paris 75252, Cedex 05, France.
5
UPMC Sorbonne Universités (Université Pierre et Marie Curie), UMR CNRS 7622, Laboratoire de Biologie du Développement, Paris 75252, Cedex 05, France mbeaudry@yahoo.fr thierry.darribere@upmc.fr.

Abstract

In aerobic organisms, oxygen is a critical factor for tissue and organ morphogenesis from embryonic development throughout the adult life. It regulates various intracellular pathways involved in cellular metabolism, proliferation, cell survival and fate. Organisms or tissues rapidly respond to changes in oxygen availability by activating complex signalling networks, which culminate in the control of mRNA translation and/or gene expression. This Commentary presents the effects of hypoxia during embryonic development, myoblasts and satellite cell proliferation and differentiation in vertebrates. We also outline the relationship between Notch, Wnt and growth factor signalling pathways, as well as the post-transcriptional regulation of myogenesis under conditions of hypoxia.

KEYWORDS:

Hypoxia; Myogenesis; Signalling

PMID:
27505427
DOI:
10.1242/jcs.188904
[Indexed for MEDLINE]
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