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Ann N Y Acad Sci. 2016 Aug;1378(1):174-179. doi: 10.1111/nyas.13177. Epub 2016 Aug 9.

Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury.

Author information

1
Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania.
2
Department of Pharmacology and Toxicology, Rutgers University, New Brunswick, New Jersey.
3
Department of Chemistry, Muhlenberg College, Allentown, Pennsylvania.
4
Department of Environmental Health Science, New York Medical College, Valhalla, New York.
5
Department of Environmental and Occupational Health, Rutgers University School of Public Health, Piscataway, New Jersey.
6
Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania. ndh0@lehigh.edu.

Abstract

The molecular pathology of sulfur mustard injury is complex, with at least nine inflammation-related enzymes and receptors upregulated in the zone of the insult. A new approach wherein inhibitors of these targets have been linked by hydrolyzable bonds, either one to one or via separate preattachment to a carrier molecule, has been shown to significantly enhance the therapeutic response compared with the individual agents. This article reviews the published work of the authors in this drug development domain over the last 8 years.

KEYWORDS:

bifunctionals; chloroethylethylsulfide; inflammation; phorbol ester; skin; sulfur mustard; vesicants

PMID:
27505078
PMCID:
PMC5063683
DOI:
10.1111/nyas.13177
[Indexed for MEDLINE]
Free PMC Article

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