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Antimicrob Agents Chemother. 2016 Sep 23;60(10):6415-7. doi: 10.1128/AAC.01325-16. Print 2016 Oct.

First Report of the Globally Disseminated IncX4 Plasmid Carrying the mcr-1 Gene in a Colistin-Resistant Escherichia coli Sequence Type 101 Isolate from a Human Infection in Brazil.

Author information

1
Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil miriamrfernandes@usp.br lincopan@usp.br.
2
Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
3
Hospital de Guarnição de Natal, Brazilian Army, Natal, Brazil.
4
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
5
School of Public Health, University of São Paulo, São Paulo, Brazil.
6
Department of Clinical Analysis, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil miriamrfernandes@usp.br lincopan@usp.br.

Abstract

A colistin-resistant Escherichia coli strain was recovered from a patient with a diabetic foot infection in Brazil. Whole-genome analysis revealed that the E. coli isolate belonged to the widespread sequence type (ST) 101 and harbored the mcr-1 gene on an IncX4 plasmid that was highly similar to mcr-1-bearing IncX4 plasmids that were recently identified in Enterobacteriaceae from food, animal, and human samples recovered on different continents. These results suggest that self-transmissible IncX4-type plasmids may represent promiscuous plasmids contributing to the intercontinental spread of the mcr-1 gene.

PMID:
27503650
PMCID:
PMC5038249
DOI:
10.1128/AAC.01325-16
[Indexed for MEDLINE]
Free PMC Article

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