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J Stroke Cerebrovasc Dis. 2016 Nov;25(11):2762-2769. doi: 10.1016/j.jstrokecerebrovasdis.2016.07.031. Epub 2016 Aug 5.

Increased Blood Viscosity in Ischemic Stroke Patients with Small Artery Occlusion Measured by an Electromagnetic Spinning Sphere Viscometer.

Author information

1
Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan; Sapporo Azabu Neurosurgical Hospital, Sapporo, Japan.
2
Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: abumiya@med.hokudai.ac.jp.
3
Department of Fundamental Engineering, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan.
4
Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
5
Sapporo Azabu Neurosurgical Hospital, Sapporo, Japan.

Abstract

BACKGROUND AND PURPOSE:

High blood viscosity causes blood stagnation and subsequent pathological thrombotic events, resulting in the development of ischemic stroke. We hypothesize that the contribution of blood viscosity may differ among ischemic stroke subtypes based on specific pathological conditions. We tried to verify this hypothesis by measuring blood viscosity in acute ischemic stroke patients using a newly developed electromagnetic spinning sphere (EMS) viscometer.

METHODS:

Measurements in acute ischemic stroke patients were performed 4 times during admission and data were compared with those obtained from 100 healthy outpatient volunteers.

RESULTS:

We enrolled 92 patients (cardioembolism: 25, large artery atherosclerosis: 42, and small artery occlusion [SAO]: 25) in this study. Comparisons of blood viscosity between the ischemic stroke subgroups and control group revealed that blood viscosity at the date of admission was significantly higher in the SAO group (5.37 ± 1.11 mPa⋅s) than in the control group (4.66 ± .72 mPa⋅s) (P < .01). Among all subtype groups showing a reduction in blood viscosity after 2 weeks, the SAO group showed the highest and most significant reduction, indicating that SAO patients had the most concentrated blood at the onset.

CONCLUSIONS:

Blood viscosity was significantly increased in the SAO group at the date of admission, which indicated the contribution of dehydration to the onset of ischemic stroke. The importance of dehydration needs to be emphasized more in the pathogenesis of SAO. The clinical application of the EMS viscometer is promising for understanding and differentiating the pathogenesis of ischemic stroke.

KEYWORDS:

Blood viscosity; dehydration; ischemic stroke; pathogenesis; rheology; small artery occlusion

[Indexed for MEDLINE]

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