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Microbiome. 2016 Aug 8;4(1):42. doi: 10.1186/s40168-016-0189-7.

Cardiorespiratory fitness as a predictor of intestinal microbial diversity and distinct metagenomic functions.

Author information

1
Department of Biology, The Irving K. Barber School of Arts and Sciences, University of British Columbia, Room ASC 386, 3187 University Way, Okanagan campus, Kelowna, British Columbia, V1V 1V7, Canada.
2
School of Health and Exercise Sciences, University of British Columbia, Okanagan campus, Kelowna, British Columbia, V1V 1V7, Canada.
3
Department of Biology, The Irving K. Barber School of Arts and Sciences, University of British Columbia, Room ASC 386, 3187 University Way, Okanagan campus, Kelowna, British Columbia, V1V 1V7, Canada. deanna.gibson@ubc.ca.

Abstract

BACKGROUND:

Reduced microbial diversity in human intestines has been implicated in various conditions such as diabetes, colorectal cancer, and inflammatory bowel disease. The role of physical fitness in the context of human intestinal microbiota is currently not known. We used high-throughput sequencing to analyze fecal microbiota of 39 healthy participants with similar age, BMI, and diets but with varying cardiorespiratory fitness levels. Fecal short-chain fatty acids were analyzed using gas chromatography.

RESULTS:

We showed that peak oxygen uptake (VO2peak), the gold standard measure of cardiorespiratory fitness, can account for more than 20 % of the variation in taxonomic richness, after accounting for all other factors, including diet. While VO2peak did not explain variation in beta diversity, it did play a significant role in explaining variation in the microbiomes' predicted metagenomic functions, aligning positively with genes related to bacterial chemotaxis, motility, and fatty acid biosynthesis. These predicted functions were supported by measured increases in production of fecal butyrate, a short-chain fatty acid associated with improved gut health, amongst physically fit participants. We also identified increased abundances of key butyrate-producing taxa (Clostridiales, Roseburia, Lachnospiraceae, and Erysipelotrichaceae) amongst these individuals, which likely contributed to the observed increases in butyrate levels.

CONCLUSIONS:

Results from this study show that cardiorespiratory fitness is correlated with increased microbial diversity in healthy humans and that the associated changes are anchored around a set of functional cores rather than specific taxa. The microbial profiles of fit individuals favor the production of butyrate. As increased microbiota diversity and butyrate production is associated with overall host health, our findings warrant the use of exercise prescription as an adjuvant therapy in combating dysbiosis-associated diseases.

KEYWORDS:

Butyrate; Community diversity; Dysbiosis; Exercise; Intestinal microbiota; Metagenome; Microbial ecology; Physical activity

PMID:
27502158
PMCID:
PMC4976518
DOI:
10.1186/s40168-016-0189-7
[Indexed for MEDLINE]
Free PMC Article

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